How much does a sperm DNA fragmentation test cost?

How much a sperm DNA fragmentation test costs

We checked each provider’s website on Nov 14, 2026. Each price is for one test that includes both a semen analysis and a DNA fragmentation result.

Sapyen also offers $379 per test if you join its retesting plan. Most providers count results time from when the lab gets your sample. Sapyen counts from the day you mail it. See the full comparison.

What the price includes

You’re paying for three things: the kit and shipping, the lab work, and help understanding your results.

• Kit and shipping: SwimScore, Legacy and Sapyen include the collection kit and prepaid return shipping. Legacy and Sapyen add a liquid that protects the sample on the way.
• Semen analysis: all three check sperm count, movement (motility) and shape (morphology). Sapyen also reports pH and clumping.
• DNA fragmentation: all three give a DNA fragmentation index (DFI). Legacy uses SCD, and SwimScore told us it uses SCD too. Sapyen doesn’t name its method.
• Help with results: SwimScore includes a physician consultation and clinical review. Legacy offers a results dashboard and fertility specialists. Sapyen’s report includes recommendations.

Why DNA fragmentation test prices differ

• The lab method. Methods use different equipment and take different amounts of work. SCSA uses a machine that reads thousands of sperm. SCD is read under a microscope. COMET takes a lot of hands-on work, and fewer labs offer it.¹²
• What’s bundled. Every price here includes a full semen analysis, so you aren’t paying for two separate tests.
• Speed and support. Legacy says its report takes 24–48 hours after its lab gets your sample. SwimScore says 2–3 business days. Sapyen says up to 10 business days from mailing.
• Retesting. New sperm take about three months to develop, so repeat tests are usually months apart. Sapyen’s retesting plan lowers its price to $379 per test.

Paying for a DNA fragmentation test

Coverage depends on your plan. Legacy says its test is HSA/FSA eligible and lists in-network coverage with some insurers and fertility benefits providers.

SwimScore and Sapyen don’t mention HSA/FSA eligibility on the pages we checked. Ask the provider or your plan before you buy.

Is the cheapest test the right one for you?

It can be. If you want both results at home and your clinician doesn’t need a specific method, a lower price is a reasonable way to choose.

Two things are worth checking first:

• Does your clinician want a particular method, such as SCSA or TUNEL? Each method has its own scale, so results aren’t interchangeable.²
• Will you retest? If so, use the same method and, ideally, the same lab, so the numbers can be compared.

Testing isn’t necessary for everyone. Guidelines differ, and testing is most often discussed in specific situations, such as repeated miscarriage or infertility with no clear cause.¹³ Our guide on who might consider testing explains more.